Guo, Zhiqiang; Bergeron, Karl-Frédérik; Lingrand, Marine et Mounier, Catherine
(2023).
« Unveiling the MUFA–Cancer Connection: Insights from
Endogenous and Exogenous Perspectives ».
International Journal of Molecular Sciences, 24, p. 9921.
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Résumé
Abstract: Monounsaturated fatty acids (MUFAs) have been the subject of extensive research in the
field of cancer due to their potential role in its prevention and treatment. MUFAs can be consumed
through the diet or endogenously biosynthesized. Stearoyl-CoA desaturases (SCDs) are key enzymes
involved in the endogenous synthesis of MUFAs, and their expression and activity have been found
to be increased in various types of cancer. In addition, diets rich in MUFAs have been associated
with cancer risk in epidemiological studies for certain types of carcinomas. This review provides an
overview of the state-of-the-art literature on the associations between MUFA metabolism and cancer
development and progression from human, animal, and cellular studies. We discuss the impact of
MUFAs on cancer development, including their effects on cancer cell growth, migration, survival,
and cell signaling pathways, to provide new insights on the role of MUFAs in cancer biology
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