Toward a better understanding of enteric gliogenesis

Charrier, Baptiste et Pilon, Nicolas (2017). « Toward a better understanding of enteric gliogenesis ». Neurogenesis, 4(1), e1293958.

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Most of gastrointestinal functions are controlled by the enteric nervous system (ENS), which contains a vast diversity of neurons and glial cells. In accordance with its key role, defective ENS formation is the cause of several diseases that affect quality of life and can even be life-threatening. Treatment of these diseases would greatly benefit from a better understanding of the molecular mechanisms underlying ENS formation. In this regard, although several important discoveries have been made over the years, how the full spectrum of enteric neuronal and glial cell subtypes is generated from neural crest cells during development still remains enigmatic. Because they also have stem cell properties, such knowledge would be especially important for the enteric glial cell lineage. In a recent study, we identified the NR2F1 transcription factor as a new key regulator of enteric gliogenesis. Here we discuss our recent findings and briefly review what is already known about the mechanisms and signaling pathways involved in enteric gliogenesis, with an emphasis on Hedgehog and Notch signaling.

Type: Article de revue scientifique
Informations complémentaires: This is an Accepted Manuscript of an article published by Taylor & Francis in Neurogenesis on 02/03/2017, available online:
Mots-clés ou Sujets: enteric glial cells, enteric nervous system, gliogenesis, Hirschsprung disease, neural crest cells, Notch, Hedgehog, NR2F1, NR2F2, Waardenburg syndrome
Unité d'appartenance: Centres institutionnels > Centre de recherches biomédicales (BIOMED)
Faculté des sciences > Département des sciences biologiques
Déposé par: Jean-Jacques Rondeau
Date de dépôt: 18 janv. 2019 11:15
Dernière modification: 18 janv. 2019 11:15
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